Table 1.

Top-associated SNPs of the meta-analysis of both GWAS on plasma α-Klotho levels

SNP	Chr.	EA	OA	EAF	Gene	β	SE	P	Pair-wise Z	P_Z
rs12607664	18	T	G	31.61	CHST9	0.243	0.022	2.28 × 10−27	3.337	0.001
rs8176672	9	T	C	7.18	ABO	0.406	0.041	2.11 × 10−23	1.785	0.074
rs532436	9	G	A	23.99	ABO	0.204	0.026	5.86 × 10−15	0.691	0.490
rs1056008	12	C	T	26.82	B4GALNT3	0.184	0.024	1.80 × 10−14	0.478	0.632
rs7333961	13	A	G	4.62	KL	−0.327	0.051	1.73 × 10−10	0.816	0.415
rs881301	8	C	T	41.28	FGFR1	−0.119	0.021	2.23 × 10−08	0.087	0.931

The effect size (β) represents SD difference in α-Klotho relative to the mean (i.e. Z-score) per effect allele. Results show univariate/simple linear regression estimates for the six conditionally independent SNPs. The effect size (β) represents SD difference in α-Klotho relative to the mean (i.e. Z-scores) per effect allele. Chr., chromosome; EA, effect allele; OA, other allele; EAF, effect allele frequency in the pooled sample in percentage; SE, standard error. Pair-wise Z and P_Z are the pair-wise Z estimating the difference between two effect estimates (in LURIC and ALSPAC) and P-value of the Z-score.