Table 2.
LD score regression between α-Klotho and human traits (for associations with P < 0.05)
| Trait 1 | Trait 2 | r g | SE | Z | P |
|---|---|---|---|---|---|
| α-Klotho | Excessive frequent and irregular menstruation | 0.48 | 0.21 | 2.3 | 0.02 |
| α-Klotho | Fibroblastic disorders | −0.38 | 0.17 | −2.2 | 0.03 |
| α-Klotho | Triglycerides in small VLDL | −0.54 | 0.24 | −2.2 | 0.03 |
| α-Klotho | Chronotype | −0.17 | 0.08 | −2.1 | 0.03 |
| α-Klotho | Crohn’s disease | 0.25 | 0.12 | 2.1 | 0.03 |
| α-Klotho | Eczema | −0.48 | 0.23 | −2.1 | 0.04 |
| α-Klotho | Co-codamol | 0.44 | 0.21 | 2.1 | 0.04 |
| α-Klotho | Prostate cancer | 0.49 | 0.25 | 2.0 | 0.05 |
r g, genetic correlation; SE, standard error of the genetic correlation analysis; Z, corresponding Z-score; P, corresponding P-value; VLDL, very low-density lipoprotein.