Fig. 3.

Human pathway annotation can be propagated through interactors to improve bacterial pathway annotation. A Paired stacked bar plots showing the 1102 disease-associated bacterial protein clusters according to whether they are able to be annotated by KEGG (left) and their inferred pathways according to the human proteins they target (right), as annotated by WikiPathways [77]. B Proportions of the bacterial clusters in the HBNet, Detected and Disease-associated subsets according to their COG functional categories are plotted. p values are depicted by * p<0.05; ** p<0.01; *** p<0.001; **** p<0.0001 (chi-square test). Total numbers of each set are noted in the legend