Fig. 4.
Human proteins targeted by gut commensal proteins include known therapeutic drug targets. A Nafamostat, B imatinib, and C artenimol target human proteins that are differentially targeted by bacterial proteins detected in the stated metagenomic studies. Log10 relative mean summed abundances of bacterial interactors in patients versus controls are provided. p-values were calculated by the Mann-Whitney rank-sum test, * p<0.05; ** p<0.01; *** p<10−3; **** p<10−4). Full taxa and UniRef numbers for all bacterial proteins shown are provided in Additional file 7: Table S6