Fig. 4.

External validation with DrugBank datasets. A Change in the proportions of true positives and false positives predicted in DrugBank verv5.0.0 compared with v.5.1.7. More than 35% of drug pairs were found to be interactions present in the new version. B Result of the permutation test. The grey distribution is from 10,000 random samplings, and the red line indicates the number of drug pairs found in the updated DrugBank version. C Proportion of each DDI case of validated drug pairs. Most cases were one-unseen and both-unseen drug cases