Table 1.
Acute oral toxicities to ivermectin for Anopheles species using in vitro membrane feeding techniques, ranked according to susceptibility
| Anopheles species | Mosquito strain and history* | Mortality assessment period (day) | N | Oral LC50 (95% CL) | References |
|---|---|---|---|---|---|
| stephensi | STE2; Long-standing | 4 | 573 | 7 (5, 9) | [16] |
| arabiensis | DONGOLA; Long-standing | 9 | 515 | 8 (6, 10) | [7] |
| minimus | AFRIMS; Long-standing | 7 | 2376 | 16 (12, 19) | [13] |
| gambiae s.s. | KISUMU; Long-standing | 9 | Not reported | 20 ± 3 | [2] |
| gambiae s.s. | G3; Long-standing | 5 | 2013 | 22 (18, 27) | [5] |
| albimanus | BELIZE; Field-collected | 4 | 352 | 26 (14, 51) | Present study |
| campestris | AFRIMS; Long-standing | 7 | 2786 | 26 (22, 30) | [13] |
| sawadwongporni | AFRIMS; Long-standing | 7 | 1446 | 27 (25, 29) | [13] |
| darlingi | NAMRU-6; Recent | 7 | 6161 | 43 (37, 49) | [14] |
| aquasalis | FMT-HVD; Long-standing | 5 | 1415 | 47 (45, 49) | [11] |
| dirus | AFRIMS; Long-standing | 7 | 5029 | 56 (52, 59) | [13] |
| albimanus | STECLA; Long-standing | 4 | 582 | 1468 (1153, 1965) | [16] |
* ‘Long-standing’ is defined as more than 5 years of continuous colony prior to testing. ‘Recent’ is defined as two to three years in colony prior to testing