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. 2022 Mar 3;22:101. doi: 10.1186/s12935-022-02467-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Function network of LMNB1 and LMNB1-related genes in TCGA. A GEPIA2 was used to acquire the top 100 LMNB1-correlated genes across all TCGA cancers. TMPO, KIF11, NUSAP1, KIF15, MCM6 and PLK4 were the most six correlated genes with LMNB1. B STRING network was used to obtain the top 50 genes of which the corresponding proteins have been experimentally determined lamin B1-binding. C The venn diagram visualized the intersection of LMNB1-correlated genes and lamin B1-binding proteins. D KEGG pathway analysis was conducted using LMNB1-correlated genes and lamin B1-binding proteins. E Biological process GO term enrichment analysis based on LMNB1-related partners was also performed. F Genes involved in the most enriched process were plotted