Skip to main content
. 2022 Feb 24;2022:3589525. doi: 10.1155/2022/3589525

Figure 5.

Figure 5

Effect PDK inhibitor (dichloroacetate) on expression of enzymes involved in lipid metabolism, gluconeogenesis, and multiple hepatic signaling pathways. (a) Relative mRNA levels of PDK4 and relevant glycolytic and lipogenic genes in the livers of FXR-null, wild-type mice fed high fat diet with DCA treatment. ∗∗P < 0.01, relative to wild-type mice fed high fat diet, #P < 0.05, ##P < 0.01, ###P < 0.001, relative to FXR-null mice fed high-fat diet with DCA treatment, n = 3. (b) Representative Western blots are shown for the amounts of Fasn, Srebp-1c, Scd1, Acc1, PGC-1α, mTOR/p-mTOR, p-AMPK, p-p38, PDK4, Acly, and GCK in the livers of wild-type or FXR-null mice fed the high-fat diet with DCA treatment. Tubulin served as the loading control.