Figure 5.

scLink identifies differential co-expression relationships between normal and breast cancer tissues. A. The log₁₀-transformed expression of two gene pairs (NUDT3 and EGR1; FNBP1 and MGP) which were connected in the scLink network in immune cells of the normal tissue but not in the tumor tissue. Both scLink’s and Pearson correlation coefficients are displayed. B. The log₁₀-transformed expression of two gene pairs (CD63 and BIRC3; EGR1 and USF2) which were connected in the scLink network in immune cells of the tumor tissue but not in the normal tissue. C. The correlation matrices (in the normal and tumor tissues) of a 15-gene module identified by scLink from the immune cells in the normal tissue. Genes showing opposite co-expression relationships with the other genes between the two conditions are highlighted in bold.