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. 2022 Feb 18;9:839617. doi: 10.3389/fmolb.2022.839617

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Copyright © 2022 Du, Wang, Kong, Wu, Chen, Lyu, Zhou and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA). GSEA biological function enrichment analysis shows activation of the immune response (A) and adaptive immune response (B). GSEA biological pathway enrichment analysis results show cytokine-cytokine receptor interaction (C) and adaptive immune response (D). (E) Heat map of significant hallmarks analyzed using GSVA. Scatter plot of correlation between significant hallmark and risk score: reactive_oxygen_species_pathway (F), spermatogenesis (G), and uv_response_dn (H).