Table 1.

Previous trials evaluating the role of midodrine for hypotension

Author	Year	Patients	Population	Study type	Outcomes	Results
Levine et al.	2013	20	Surgical	Single-center prospective cohort	• Dose of IV vasopressor	• Decrease of −1.58 mcg/min of phenylephrine with use of midodrine
Poverno et al.	2016	188	General	Single-center retrospective cohort	• Duration of IV vasopressor • ICU LoS • Hospital LoS • ICU readmission	• Midodrine patients required IV vasopressors for 1.2 days following initiation of midodrine • No change in ICU length of stay • Increased hospital length of stay with midodrine (12.0 vs. 9.5days) • No difference in ICU readmission between groups
Whitson et al.	2016	275	Medical	Single-center retrospective cohort	• Duration of IV vasopressor • ICU LoS • Hospital LoS • IV vasopressor reinstitution • Mortality	• Decrease duration of IV vasopressors by 0.9 days • Decrease ICU length of stay (7.5 days vs. 9.4 days) with midodrine • Decrease hospital length of stay (21.9 days vs. 24.2 days) with midodrine • No mortality difference between groups
Santer et al.	2020	136	General	Multicenter RCT	• Duration of IV vasopressor • ICU LoS • Hospital LoS • ICU readmission • Adverse events	• No difference in duration of IV vasopressors • No difference in ICU or hospital LoS • No difference in ICU readmissions between groups