Fig. 5.

Clock-based therapy in cancer management. a directly pharmacological targeting circadian clock for cancer therapy. Targeting the components of circadian clock has attracted much attention as a therapeutic approach to treat cancer. There are several pharmacologic agents targeting the components of circadian clock, including REV-ERBα/β, RORα/β/γ, CRY1/2, Casein Kinase family, and FBXL3. b, the effect of modulating circadian rhythms on conventional cancer therapy. Modulating the sleep–wake, eating–fasting, and activity–rest cycles can benefit the effect of chemotherapy, radiotherapy, and immunotherapy