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. Author manuscript; available in PMC: 2022 Mar 4.
Published in final edited form as: Bioorg Med Chem Lett. 2021 Oct 16;53:128414. doi: 10.1016/j.bmcl.2021.128414

Figure 4. Serine hydrolase engagement profiles for palmostatin analogs determined by MS-ABPP using the FP-biotin probe.

Figure 4.

Venn diagram depicting serine hydrolases showing substantial engagement (> 50%) by Palm M (10 μM), 12 (20 μM), and/or 1 (20 μM) in OCI-AML3 cells as determined by MS-ABPP (also see Supp. Table 1). Palm M targets listed from previously published dataset14. MS-ABPP data represent average values from independent experiments (n = 3 for 12, n = 2 for 1).