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. 2022 Feb 28;15:1437–1456. doi: 10.2147/JIR.S348786

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© 2022 Su et al.

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Canonical pathway analysis using GSEA and the relationship between TLR3 and related genes of signaling pathways, cytokines, and chemokines. (A) The most significant pathways in terms of the hallmark gene sets. (B) The most significant pathways in terms of the immunologic signature gene sets. (C) The most significant pathways in terms of the curated gene sets. (D) Correlations between TLR3 expression and gene expression changes in the apoptosis and complement signaling pathways (i), and cytokines and chemokines patterns (ii) in the tumor immune microenvironment. *P < 0.05, **P < 0.01, ***P < 0.001.