Figure 5.

Variant-disrupted disease genes affect the modularity of the individual's regulatory network in the relevant cell type. Differential modularity (DM) scores indicate the extent to which a gene's modular environment in the network changes between the genotype-specific EGRET network and the genotype-agnostic network. (A) CAD-related genes with high DM scores in cardiomyocytes (CMs) have low DM scores in the other cell types. (B) CD-related genes with high DM scores in LCLs have low scores in the other cell types (see Supplemental Table S2).