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. 2022 Mar;32(3):558–568. doi: 10.1101/gr.275533.121

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© 2022 Joseph et al.; Published by Cold Spring Harbor Laboratory Press

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Figure 5. — PTRs are highly personalized and uncorrelated with relative abundances. (A) Fraction of variance of log₂(PTR) explained per species by variation between individuals, disease-statuses, age, and sex. Inter-individual variation accounts for most variation among log₂(PTR)s of the variables explored. (B) Boxplots of the log₂(PTR) (x-axis) of Parabacteroides distasonis across individuals (y-axis). P. distasonis had the smallest P-value when testing for individual differences using the Kruskal–Wallis test on controls. PTRs appear stable within individuals. (C) Correlation between standardized log₂(PTR) and log₂(relative abundance) on species matched to relative abundances estimated with MetaPhlAn2.