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. 2022 Feb 9;2(2):100098. doi: 10.1016/j.xgen.2022.100098

Figure 5.

Figure 5

Constructing models with CASCADE for SNP-eQTLs

(A) Left column: CASCADE-determined COF recruitment motifs for p300, SMARCA4, TBL1XR1, GCN5, and RBBP5 at the local genomic region surrounding rs11950944. PU.1 binding motif is also shown. Right column: TF binding motif with the strongest association to each corresponding CASCADE COF recruitment motif. Statistical significance (p value) for TF matching is shown below each TF motif (see STAR Methods). Position of the SNP location within each motif is shown in the shaded area. QTL type and inferred TF category are indicated by the same color scheme as in Figure 4.

(B) Same as in (A) but for the local genomic region surrounding rs10833823. Only sites that met an imposed Z score threshold were plotted and used for motif analysis (see STAR Methods).

(C) Integrative model for COF recruitment changes at SNP-eQTL rs11950944.

(D) Same as in (C) but for SNP-eQTL rs10833823. See also Table S1 and Figures S5, S6, and S7.