Fig. 6.

Taxonomic contributors to microbiome-governed metabolites in two studies of IBD. (A) Heatmap of genus-level microbial contributors to fecal metabolites identified by MIMOSA2-OLS in Franzosa et al. (2018). The upper two bars show the association of each metabolite with Crohn’s disease (CD) and/or ulcerative colitis (UC), with a black dot indicating a significant association (FDR-adjusted P<0.1). Metabolites with a false discovery rate-adjusted P-value <0.25 are shown. (B) Heatmap of genus-level microbial contributors to fecal metabolites in IBDMDB Investigators et al. (2019). As in panel (A), the upper two bars show association with CD and UC (same color scale), and metabolites with an FDR-adjusted P-value <0.25 are shown