Table 6. Collagen degradation markers and caspase-3.
| Groups | P values | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| SA0 | SA2 | SA5 | IA0 | IA2 | IA5 | P (I) | P (A) | P (IxA) | |
| *TIMP-1 (pg/mg) | (6) 8.94±2.48a | (4) 9.42±0.90 | (2) 18.1±8.85 | (4) 51.4±13.5a,A,C | (4) 12.3±1.62A | (4) 8.25±1.95C | 0.055 | 0.049 | <0.0013 |
| *ICF (%) | (8) 2.19±0.3a,E,F | (8) 3.09±0.9b,F | (8) 3.08±0.3c,E | (8) 10.4±1.5a,C | (8) 10.2±1.4b,B | (8) 8.07±1.8c,B,C | <0.001 | 0.090 | <0.0013 |
| Expression Collagen I | (8) 0.73±0.13 | (6) 0.87±0.17 | (6) 0.73±0.16 | (6) 1.22±0.21 | (6) 1.18±0.29 | (6) 0.85±0.14 | 0.0501 | 0.439 | 0.603 |
| Expression Collagen III | (7) 0.84±0.09 | (6) 1.04±0.14 | (6) 1.26±0.24 | (6) 1.14±0.17 | (6) 1.00±0.07 | (6) 1.25±0.14 | 0.503 | 0.164 | 0.464 |
| Expression Caspase-3 | (8) 1.88±0.58 | (7) 2.81±0.73 | (8) 3.21±0.65 | (7) 1.58±0.42 | (8) 2.63±0.68 | (7) 2.36±0.65 | 0.397 | 0.182 | 0.853 |
I: infarction; S: sham; A: açai; A0: no supplementation; A2: 2% açai supplementation; A5: 5% açai supplementation. TIMP-1: tissue inhibitor of metalloproteinase-1; ICF: interstitial collagen fraction. Data are expressed as mean ± SEM. Bold numbers represents significant effects considered.
1 Comparisons for I factor: infarcted animals different from sham animals.
3 IxA: when interactions are observed, same superscript letters represents differences (P<0.05).
*variables normalized for 2-factor ANOVA test.
#Mann Whitney and Kruskal Wallis.