Table 2. Changes in Depression, Anxiety and Manic Symptom Severity from Baseline to Week 8 and Week 16 in Lithium Responders and lithium non-Responders.
| Assessment | Baseline M ± SD |
Week 8 M ± SD |
Lithium Responders Change from baseline M ± SD |
Week 16 M ± SD |
Change from baseline M ± SD |
Baseline M ± SD |
Week 8 M ± SD |
Lithium non-Responders Change from baseline M ± SD |
Week 16 M ± SD |
Change from baseline M ± SD |
Δ Diff at Week 8: Res vs. Non-Res P value |
Δ Diff at Week 16: Res vs. Non-Res P value |
| Blinded assessments | ||||||||||||
| MADRS | 21.69 ± 6.33 | 8.55 ± 7.92 | −13.64 ± 11.39 | 5.25 ± 2.49 | −17.63 ± 8.68 | 26.00 ± 6.32 | 16.40 ± 12.26 | −8.00 ± 12.79 | 19.25 ± 5.85 | −4.75 ± 10.78 | 0.3909 | 0.0485 |
| YMRS | 12.08 ± 6.03 | 3.36 ± 2.34 | −8.00 ± 6.25 | 2.88 ± 1.89 | −8.63 ± 5.66 | 12.45 ± 7.01 | 14.00 ± 4.06 | 2.00 ± 4.85 | 10.75 ± 1.71 | 0.00 ± 3.74 | 0.0070 | 0.0211 |
| HAMA | 16.62 ± 5.72 | 8.09 ± 5.43 | −8.09 ± 0.75 | 7.25 ± 6.61 | −8.63 ± 8.50 | 20.18 ± 7.03 | 16.60 ± 8.08 | −2.80 ± 11.15 | 18.40 ± 5.41 | −1.00 ± 11.27 | 0.2467 | 0.1911 |
| Non-blinded assessment | ||||||||||||
| CGI-S | *3.15 ± 0.80 | 1.42 ± 0.51 | −1.75 ± 0.75 | 1.50 ± 0.53 | −1.63 ± 0.92 | *4.09 ± 0.54 | 2.40 ± 1.34 | −1.40 ± 1.67 | 2.50 ± 1.00 | −1.50 ± 1.00 | 0.5512 | 0.8328 |
| Self-reported assessment | ||||||||||||
| QIDS-16-SF | 12.67 ± 4.66 | 5.00 ± 3.19 | −8.00 ± 4.03 | 3.14 ± 2.61 | −9.00 ± 2.71 | 15.27 ± 2.61 | 6.40 ± 4.04 | −9.40 ± 3.72 | 9.25 ± 3.69 | −7.00 ± 2.58 | 0.5202 | 0.2620 |
Note: *Significantly different between responders and non-responders (p = 0.0033).
Abbreviations: CGI-S, Clinical Global Impression-Severity; DIFF, difference; HAMA, Hamilton Anxiety Rating Scale; M, mean; MADRS, Montgomery-Asberg Depression Rating Scale; Non-Res, non-responders; QIDS-16-SF, the 16 item Quick Inventory of Depressive Symptomatology Self Report; Res, responders; SD, standard deviation; YMRS, Young Mania Rating Scale.