Table 3.
Recent relevant research of micelles for respiratory therapy.
| Materials | Disease | Drug | Fabrication method | Efficacy tests | Cytotoxicity tests | Reference |
|---|---|---|---|---|---|---|
| Chitosan | Tuberculosis | Rifampicin/pyrazinamide | Dialysis | In vitro MIC test | MTT assay, negligible cytotoxicity (VERO cells), high toxicity (TPH-1 cells) | [6] |
| Inulin-vitamin E | Tuberculosis | Rifampicin | Dialysis | In vitro MIC test | MTT assay (human alveolar macrophages), viability 63% (2 mg/mL) | [37] |
| Chitosan-graft-poly(caprolactone)/(ferulic acid) | Tuberculosis | Rifampicin | Dialysis | In vitro inhibition test | Hemocytometer with trypan blue exclusion (A549 cells), IC50 of ∼60 μg/mL* | [38] |
| α-tocopheryl succinate-PEG | Lung cancer | PTX | Thin-film hydration | In vitro MTT assay | MTT assay (A549 cells), IC50 ∼1.5 μg/mL* | [39] |
| Poly (vinyl caprolactam)-poly (vinyl acetate)-PEG | Tuberculosis | Rifampicin | Solvent-diffusion | In vitro MIC test | CellTiter 96® (RAW 264.7), cell viability >85% (100 μg/mL) | [40] |
| Pluronic® 123/Pluronic® F127 | Lung inflammation | Budesonide | Thin-film hydration | In vivo inflammation model (male Wistar rat) | Non reported | [41] |
| PEG-PLA/Pluronic® P105 | Lung cancer | PTX | Thin-film hydration | In vivo tumor growth inhibition (BALB/c nude mice) | MTT assay (A549 cells), IC50 ∼87.09 ng/mL | [42] |
| Soluplus®/d-α-tocopherol acid polyethylene glycol 1000 succinate)/dequalinium | Lung cancer | Hinokiflavone | Thin-film hydration | In vivo tumor growth inhibition (BALB/c nude mice) | Cell counting kit-8 (A549 cells), IC50 7.81 μg/mL | [43] |
| Cholesterol-conjugated PAMAM | Acute lung injury | Resveratrol/heme oxygenase-1 gene | Emulsification-solvent evaporation | In vivo lipopolysaccharide induce acute lung injury model (BALB/c nude mice) | MTT assay (L2 cells), cell viability >80% (15 μg/mL) | [44] |
Abbreviations in table: MIC = minimum inhibitory concentration, IC50 = half maximal inhibitory concentration, MTT = 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, VERO = african green monkey kidney epithelial cells, TPH-1 = human leukemia monocytic cells, A549 = adenocarcinomic human alveolar basal epithelial cells, RAW 264.7 = mouse leukemic monocyte-macrophage cells, * = value read from a graph.