Figure 4.

Comparison of CD31 vessel quantity. CD31 vessel quantity in the normal (a), STSG (b), FTSG (c), Matriderm® (d), and AlloDerm® (e) groups, respectively; 100x magnification, 100 μm scale bar; immunostaining technique; Hyperactive fibroblasts in hypertrophic scars secrete higher than normal levels of angiogenic factors, which promote endothelial cell proliferation and more microvessel formation. CD31 helps to promote vascular barrier function in response to inflammatory stimuli. There was a significant increase in vessel quantity expressing CD31 in the FTSG and Matriderm® groups compared to the normal group.