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. 2022 Jan 12;322(3):G383–G395. doi: 10.1152/ajpgi.00303.2021

Figure 5.

Figure 5.

Increasing dose of emodin reduces proinflammatory macrophage environment within the bone marrow of AOM/DSS mice. A: flow plots identifying mature macrophages (CD45+/CD11b+/Ly6C+/F480+ cells). B: quantification of mature macrophages. C: flow plots identifying M1-like (CD11c+) vs. M2-like (CD206+) macrophages. CD11c/CD206+ cells are considered transitioning cells and CD11c-CD206− cells are considered M0 macrophages. D: quantification of M1, transition, M2, and M0 macrophages. E: ratio of M1/M2 macrophage counts. Groups not containing the same letter (a and b) indicates statistical significance between groups (P < 0.05) from one-way ANOVA, n = 2 control and n = 4 AOM/DSS/group. AOM/DSS, azoxymethane/dextran sodium sulfate.