Skip to main content
. 2022 Jan 10;322(3):E199–E210. doi: 10.1152/ajpendo.00320.2021

Figure 3.

Figure 3.

Blocking PKA signaling with KT5750 blocks PACAP-dependent decreases in food intake and attenuates PACAP-induced decrease in body weight. A: blocking PKA signaling with KT5720 reverses PACAP-induced suppression of food intake from 5 h postinjection lasting up to 8 h. B: KT5720 attenuated PACAP-induced reduction in body weight 24 h following injection. KT5720 potentiates PACAP’s thermogenic (C) and locomotor effects (D). Data are expressed as means ± SE, *P < 0.05 (treatment vs. control), #P < 0.05 (PACAP vs. PACAP + KT5720); n = 6 rats/group. PACAP, pituitary adenylate cyclase-activating polypeptide; PKA, protein kinase A.