Table 2.
Responses to selective inhibition of VMN PACAP-dependent signaling
| Signaling Inhibitors | Food Intake | Body Weight | Core Body Temperature | Locomotor Activity | |
|---|---|---|---|---|---|
| PAC1R | PACAP 6-38 | √ | √ | √ | √ |
| PAC1R | shPAC1R | √ | √ | ND | ND |
| PKA | KT5720 | √ | √ | × | × |
| PKC | GF109203X | √ | √ | × | × |
| PAC1R trafficking | Pitstop 2 + Dyngo 4a | √ | × | ND | ND |
√, required; ×, not required; ND, not done; PACAP, pituitary adenylate cyclase-activating polypeptide; PAC1R, pituitary adenylate cyclase receptor; PKA, protein kinase A; PKC, protein kinase C; VMN, ventromedial nuclei.