Skip to main content
. 2021 Aug 5;12(2):723–734. doi: 10.1016/j.apsb.2021.08.002

Figure 1.

Figure 1

Concentration-dependent inhibition of whole-cell hTRPV3 currents expressed in HEK293 cells by natural IAA and IAB. hTRPV3 currents activated by 50 μmol/L 2-APB were inhibited by IAA (A) or IAB (B) at 50 μmol/L in the presence of 2-APB (n = 5). (C) Inhibition of whole-cell currents by increasing concentrations of IAA at 0.01–100 μmol/L (left panel) and analysis of concentration-dependent inhibition of hTRPV3 outward currents at +80 mV by IAA with fitting to a Hill equation, with an IC50 value of 2.7 ± 1.3 μmol/L (n = 5–6) (right panel). (D) Left panel, whole-cell hTRPV3 currents in response to increasing concentrations of IAB (0.01–100 μmol/L). Right panel, dose-response relationships of hTRPV3 outward currents at +80 mV inhibited by IAB with fitting to a Hill equation, with an IC50 value of 0.9 ± 0.3 μmol/L (n = 6–8). Whole-cell currents were evoked by voltage ramps from −100 mV to +100 mV for duration of 500 ms. Data are shown as the mean ± SEM.