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. 2021 Aug 5;12(2):723–734. doi: 10.1016/j.apsb.2021.08.002

Figure 3.

Figure 3

Reduction of single hTRPV3 channel open probability by IAA and IAB. (A)–(E) Left panels, representative traces recorded from an inside-out patch in the condition of vehicle (A), after addition of 300 μmol/L carvacrol (B), co-perfusion of 100 μmol/L IAA and 300 μmol/L carvacrol (C), co-perfusion of 100 μmol/L IAB and 300 μmol/L carvacrol (D), and co-perfusion of 20 μmol/L RR and 300 μmol/L carvacrol (E). Right panels, all-points histograms of single-channel current recording data as shown in left panels and their histograms were fitted to a Gauss functions. (F) Summary of hTRPV3 single channel conductance after exposure to different regulators (Car: carvacrol; RR: ruthenium red. n = 4, ∗∗∗∗P < 0.0001, compared with vehicle control). (G) Summary for calculated single hTRPV3 channel mean POPEN values in the presence of different TRPV3 modulators (n = 4, ∗∗∗∗P < 0.0001). Data are shown as the mean ± SEM; ∗∗∗∗P < 0.0001, by one-way ANOVA, followed by the Dunnet's test.