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. 2021 Aug 5;12(2):723–734. doi: 10.1016/j.apsb.2021.08.002

Figure 4.

Figure 4

IAA and IAB attenuates ear swelling and scratching behavior. (A) Schematic diagram of experimental timeline and location for generation of chronic itch and ear swelling model. (B) Representative ear appearance in wild type mice topically applied with vehicle, carvacrol (Car), IAA and IAB for 6 consecutive days. (C) Summary for right ear thickness from groups of vehicle, carvacrol, IAA and IAB for 7 consecutive days (n = 6 mice for per group, ∗∗P < 0.01, #P < 0.001, compared with carvacrol-treated group, by two-way ANOVA, followed by the Bonferroni's test). (D) Summary for spontaneous right ear scratching bouts with or without compound treatment on the Day 7 (n = 6–8 mice per group, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 by one-way ANOVA, followed by the Dunnet's test). Data are presented as the mean ± SEM.