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. 2021 Oct 15;12(2):867–875. doi: 10.1016/j.apsb.2021.09.032

Figure 4.

Figure 4

Representative micro-PET images and time–activity curves. (A) A series of coronal and transverse dynamic PET images of A549-FAP tumor-bearing mice at 5, 30, 60, 90, and 120 min p.i. of [18F]AlF-P-FAPI. The A549-FAP tumors are delineated in white arrows. (B) Time–activity curves of organs and A549-FAP tumor for 2 h p.i. of [18F]AlF-P-FAPI. (C) MIP at 60 min post-intravenous injection of [18F]AlF-P-FAPI, [18F]FAPI-42, and [68Ga]Ga-FAPI-04 with and without DOTA-FAPI-04 as a competitor. Shoulder joint (SJ); tumor (T); gall bladder (GB); liver (L); bladder (BL). (D) Time−activity curves of A549-FAP tumor uptake for 1 h p.i. of [18F]AlF-P-FAPI, [18F]FAPI-42, and [68Ga]Ga-FAPI-04 with and without DOTA-FAPI-04 as a competitor. (E) The ratios of tumor-to-muscle for 1 h p.i. of [18F]AlF-P-FAPI, [18F]FAPI-42, and [68Ga]Ga-FAPI-04, respectively.