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The circadian clock regulates metabolism and mitochondrial function in various model systems. Disturbances in the sleep/wake cycle in aging people and AD patients were prominent disruptive symptoms. Thus, restricted light, restricted food intake, and reagents that modulate the circadian clock, such as melatonin, coffee, and REV-ERB agonists and antagonists, are being considered for targeting whole-body and mitochondrial metabolism in the context of AD therapy.
