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Currently, more women than men have AD. However, this may be due to socioeconomic or lifespan differences between men and women. It has been shown that men with AD die earlier than women with AD. Even though there is no difference in lifespan between sexes, mitochondrial complex I and II activities are different between sexes in the 3xTg AD model. In the hAPP model, the X chromosome has been shown to extend survival and enhance cognition.
