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. 2021 Oct 21;12:153–168. doi: 10.1016/j.bioactmat.2021.10.013

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — Transcriptomic analysis. A) Volcano plot for Differentially expressed genes. Red dots marked up-regulated genes; Blue dots marked down-regulated genes. Top 15 genes with the highest abs (logFC) values were labeled. B) Heat map for showing the differentially expressed genes related to “inflammatory activation related genes” after MS@MCL treatment under lactate stimulation. C) GO enrichment bubble plot for all differentially expressed genes. Red circles represented Biological Pathway; blue circles represented Cellular Component; grey circles represented Molecular Function. Top 5 enrichment terms for each category were shown. D) KEGG enrichment analysis for studying the pathways of inflammatory activation. E) The top 1 PPI network cluster detected by cytoscape pluggin mcode. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)