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Schematic illustrations of nanozyme-functionalized hydrogel microsphere and degenerative NP tissue regenerative process. A) Preparation steps of MCL nanozyme. B) Microfluidic fabrication of injectable HAMA microsphere and grafting nanozyme onto microsphere via covalent bond (MS@MCL). C) In situ injection of MS@MCL into rat caudal IDD model for local lactate exhaustion and NP regeneration.
