FIGURE 10.

Influx and efflux of intra-axial fluid follows the arterial and venous vascular territories in the human and rodent brain. Cerebrospinal fluid (CSF) enters the brain along the arterial vascular system of the brain that consists primarily of the 3 large cerebral arteries: the anterior cerebral artery (ACA), the middle cerebral artery (MCA), and the posterior cerebral artery (PCA). Intra-axial fluid exits along the perivascular spaces surrounding the draining venous system, which consists of a superficial and deep system.