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. 2021 May 26;12(2):774–786. doi: 10.1016/j.apsb.2021.05.019

Figure 3.

Figure 3

XH30 induced G1 cell-cycle arrest in glioblastoma cells. (A) XH30 induced U87MG cell cycle arrest in G1 phase. Exposure to various concentrations of XH30 at indicated concentrations (4, 20, 100 and 500 nmol/L) or PF-04691502 (500 nmol/L) for 24 h. The cells were stained with PI for flow cytometry analysis, n = 3. (B) XH30 induced U251 cell cycle arrest in G1 phase. Exposure to various concentrations of XH30 at indicated concentrations (4, 20, 100 and 500 nmol/L) or PF-04691502 (500 nmol/L) for 24 h. The cells were stained with PI for flow cytometry analysis, n = 3. (C) XH30 downregulated the markers of G1 cell-cycle. The protein levels of cyclin D1 and CDK2 were detected via immunoblotting in both U87MG and U251 cells exposure to XH30 for 24 h.