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. 2021 May 26;12(2):774–786. doi: 10.1016/j.apsb.2021.05.019

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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XH30 repressed glioblastoma growth in glioblastoma orthotopic models. (A) Life survival curve of XH30 in U251 orthotopic model. The mice were orally administered by vehicle or XH30 for ten days, and then monitored. n = 6, ANOVA analysis, ∗∗P < 0.01, compared to vehicle group. (B) Representative MRI images from U251 orthotopic model on Day 11. Red arrow indicated tumor. (C) The tumor volumes in U251 orthotopic model on Day 11. n = 6, ANOVA analysis, ∗∗∗P < 0.001, compared to vehicle group. (D) Histological analysis of tumor issues in mouse brain of U251 orthotopic model on Day 11. Ki-67, p-AKT (S473), p-S6RP (S240/S244), IL-17A and IL-17RA staining, scale bar: 50 μm. HE staining, scale bar: 250 μm.