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. 2021 Aug 13;12(2):952–966. doi: 10.1016/j.apsb.2021.08.008

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© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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(A) The ingenuity pathway analysis (IPA) image between HIF1α and tumor metastasis in the biological network. (B) Overall and five-year survival curves breast cancer patients (BRCA) with high or low expression of HIF1α, which were obtained from the TCGA (https://ualcan.path.uab.edu/). (C) Intratumoral CD44 and MMP9 level after the PBS or co-nanoassemblies treatment (n = 4). Significance between every two groups was calculated using unpaired two-tailed Student's t-test. ∗∗P < 0.01. Data are mean ± SD.