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The novel allosteric Pocket Z of SIRT6 was identified by computational methods (A) Conformational landscape of apo SIRT6. (B) Conformational landscape of holo SIRT6. (C) The novel allosteric site Pocket Z in S3′ within the conformational ensemble of holo SIRT6. (D) Energy coupling analysis of Pocket Z. (E) Pocket Z is located topologically distal to the orthosteric NAD+ binding site.
