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. 2021 Jul 2;12(2):876–889. doi: 10.1016/j.apsb.2021.06.015

Figure 6.

Figure 6

JYQ-42 inhibits SIRT6 deacetylation and cell migration of pancreatic cancer cells. (A) Western blot analysis of SIRT6 and its substrates H3K9Ac, H3K18Ac and H3K56Ac in BXPC-3 cells treated with the indicated doses of JYQ-42 for 24 h. (B) Kinetic curves of the migration of BXPC-3 cells in the absence or presence of 5, 10, 20 μmol/L JYQ-42, as determined by xCELLigence RTCA-DP. Data are presented as the mean ± SD, n = 3 wells, from three independent experiments. ∗∗∗∗P < 0.0001, t-test (two-tailed and unpaired). (C) Representative images of wound-healing assays of BXPC-3 cells in the absence or presence of 10, 20, 40 μmol/L JYQ-42 obtained under phase contrast microscopy. Scale bar, 100 μm. The images shown are representative of triplicate experiments.