Table 2.
Target selectivity of JYQ-42 for HDACs and sirtuins.
| Enzyme | Effect | Activity IC50 (μmol/L)a |
|---|---|---|
| HDAC1 | ND | ND |
| HDAC2 | ND | ND |
| HDAC3 | ND | ND |
| HDAC4 | ND | ND |
| HDAC5 | ND | ND |
| HDAC6 | ND | ND |
| HDAC7 | ND | ND |
| HDAC8 | ND | ND |
| HDAC9 | ND | ND |
| HDAC10 | ND | ND |
| HDAC11 | ND | ND |
| SIRT1 | ND | ND |
| SIRT2 | Inhibition | 87.2 ± 1.1 |
| SIRT3 | ND | ND |
| SIRT5 | ND | ND |
| SIRT6 | Inhibition | 2.33 ± 0.17 |
| SIRT7 | ND | ND |
a
The activity values are calculated based on IC50 for the inhibition effect. ND had no detectable inhibitory effect on the targets in the presence of JYQ-42 at 100 μmol/L. Data are presented as the mean ± SD from three independent experiments.