Fig. 2.

Chemical compositions of the ionizable lipids (top) DLin-MC3-DMA (MC3) used in Onpattro® liposomes to deliver siRNA targeting transthyretin for the treatment of polyneuropathy associated with hereditary transthyretin amyloidosis (hATTR), republished with permission from Jayaraman et al. [43], (middle) sphingomyelin-102 (SM-102) used in liposomes to deliver mRNA for vaccination against COVID-19 developed by Moderna Therapeutics Inc., and (bottom) ALC-0315 used in liposomes to deliver mRNA for vaccination against COVID-19 developed by Pfizer-BioNTech, both reprinted from Buschmann et al. [36] under the Creative Common CC BY License.