Table 3.

Performance of glycated albumin to identify undiagnosed diabetes at selected thresholds in US adults, NHANES 1999–2004.^a

Threshold	Sensitivity (95% CI)	Specificity (95% CI)	Positive predictive value (95% CI)	Negative predictive value (95% CI)
FPG ≥126 mg/dL (≥6.99 mmol/L) (reference)
Glycated albumin ≥16.5%	0.376 (0.282–0.480)	0.981 (0.974–0.986)	0.381 (0.269–0.507)	0.980 (0.975–0.985)
Glycated albumin ≥17.8%	0.284 (0.198–0.389)	0.992 (0.985–0.995)	0.514 (0.338–0.685)	0.978 (0.972–0.982)
Hb A1c ≥6.5%	0.463 (0.368–0.561)	0.996 (0.994–0.997)	0.782 (0.675–0.861)	0.983 (0.979–0.987)
HbA 1c ≥6.5% (reference)
Glycated albumin ≥16.5%	0.628 (0.485–0.751)	0.981 (0.975–0.986)	0.377 (0.278–0.488)	0.993 (0.989–0.996)
Glycated albumin ≥17.8%	0.502 (0.375–0.629)	0.992 (0.986–0.996)	0.538 (0.371–0.697)	0.991 (0.987–0.994)
FPG ≥126 mg/dL	0.782 (0.675–0.861)	0.983 (0.979–0.987)	0.463 (0.368–0.561)	0.996 (0.994–0.997)
Hb A1c ≥6.5% and FPG ≥126 mg/dL (≥6.99 mmol/L) (reference)
Glycated albumin ≥16.5%	0.707 (0.568–0.815)	0.980 (0.973–0.985)	0.332 (0.236–0.445)	0.996 (0.993–0.997)
Glycated albumin ≥17.8%	0.591 (0.450–0.719)	0.991 (0.985–0.995)	0.495 (0.332–0.659)	0.994 (0.991–0.996)
Hb A1c ≥6.5% or FPG ≥126 mg/dL (≥6.99 mmol/L) (reference)
Glycated albumin ≥16.5%	0.372 (0.280–0.475)	0.982 (0.975–0.987)	0.426 (0.311–0.551)	0.978 (0.972–0.982)
Glycated albumin ≥17.8%	0.273 (0.195–0.367)	0.992 (0.986–0.996)	0.556 (0.379–0.721)	0.975 (0.968–0.980)

^aGlycated albumin values of 16.5% and 17.8% are “equivalent” (i.e., the same percentile) as a FPG of 126 mg/dL (≥6.99 mmol/L) and Hb A_1c of 6.5% in US adult without di- agnosed diabetes.