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. Author manuscript; available in PMC: 2023 Mar 15.
Published in final edited form as: J Mol Biol. 2021 Dec 20;434(5):167413. doi: 10.1016/j.jmb.2021.167413

Figure 2. 2D and 3D structures of the A2Moo tetramers.

Figure 2.

(A) Representative 2D class averages of the native-form A2Moo tetramer mimic previously proposed depictions of A2M architectures. (B) 3D atomic model of the native-form A2Moo tetramer. Two pairs of “connected mitten”-shaped A2M dimers stack to form a cross-like configuration with D2 symmetry, where each monomer consists of a “bulky finger” module, a “thumb” module, and a “palm” module. (C) 3D atomic model of the intermediate-form A2Moo tetramer. The “bulky finger” module folds toward the “wrist”. (D) Atomic model of the induced-form human A2M (PDB ID: 4ACQ) [7].