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. Author manuscript; available in PMC: 2023 Mar 3.
Published in final edited form as: Mol Cell. 2022 Jan 14;82(5):891–906. doi: 10.1016/j.molcel.2021.12.007

Figure 2: Chemical structures of some tRNA modifications assessable by next-gen sequencing.

Figure 2:

Modified chemical moieties are shown in red. (A) W-C face modifications: N1-methyladenosine (m1A), N1-methylguanosine (m1G), N2,2-dimethylguanosine (m22G), N3-methylcytidine (m3C), N3-(3-amino-3-carboxypropyl)uridine (acp3U). (B) After chemical treatment: 5-methylcytidine (m5C), pseudouridine (Ψ), dihydrouridine (D), N7-methylguanosine (m7G).