Table2.
Prognostic factors identified by uni- and multivariate COX regression analyses in the training cohort.
| Characteristics | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Age group, years | < 0.0001 | < 0.0001 | ||
| < 50 | Reference | Reference | ||
| 50–69 | 1.10 (0.96–1.26) | 0.180 | 1.16 (1.01–1.33) | 0.032 |
| ≥ 70 | 1.55 (1.35–1.79) | < 0.0001 | 1.61 (1.38–1.87) | < 0.0001 |
| Sex | 0.135 | – | ||
| Female | Reference | – | – | |
| Male | 0.74 (0.51–1.10) | 0.135 | – | – |
| Race | < 0.0001 | < 0.0001 | ||
| White | Reference | Reference | ||
| Black | 1.29 (1.15–1.45) | < 0.0001 | 1.35 (1.20–1.52) | < 0.0001 |
| Others | 0.79 (0.66–0.96) | 0.016 | 0.85 (0.70–1.02) | 0.080 |
| Laterality | 0.844 | – | ||
| Left | Reference | – | – | |
| Right | 0.97 (0.89–1.07) | 0.599 | – | – |
| Others | 1.08 (0.54–2.17) | 0.830 | – | – |
| Histologic type | 0.034 | 0.001 | ||
| DC | Reference | Reference | ||
| LC | 1.23 (0.97–1.57) | 0.086 | 1.41 (1.10–1.81) | 0.006 |
| Others | 1.15 (1.01–1.32) | 0.037 | 1.21 (1.05–1.38) | 0.007 |
| Grade | < 0.0001 | < 0.0001 | ||
| Grade1 | Reference | Reference | ||
| Grade2 | 1.28 (1.01–1.63) | 0.043 | 1.34 (1.05–1.71) | 0.018 |
| Grade3 | 1.80 (1.42–2.28) | < 0.0001 | 1.87 (1.46–2.40) | < 0.0001 |
| Grade4 | 2.07 (1.19–3.61) | 0.010 | 2.06 (1.17–3.63) | 0.012 |
| Subtype | < 0.0001 | < 0.0001 | ||
| HR+/HER2− | Reference | Reference | ||
| HR+/HER2+ | 0.81 (0.70–0.94) | 0.005 | 0.92 (0.79–1.07) | 0.267 |
| HER2 | 1.15 (0.97–1.35) | 0.108 | 1.37 (1.14–2.64) | 0.001 |
| TN | 2.36 (2.10–2.65) | < 0.0001 | 2.77 (2.42–3.18) | < 0.0001 |
| T | < 0.0001 | 0.006 | ||
| T0 | Reference | Reference | ||
| T1 | 0.69 (0.29–1.69) | 0.420 | 0.77 (0.32–1.89) | 0.573 |
| T2 | 0.72 (0.29–1.74) | 0.462 | 0.76 (0.32–1.85) | 0.551 |
| T3 | 0.79 (0.33–1.92) | 0.606 | 0.81 (0.33–1.96) | 0.639 |
| T4 | 0.91 (0.38–2.19) | 0.828 | 0.94 (0.39–2.26) | 0.883 |
| N | 0.106 | – | ||
| N0/N1mi | Reference | – | – | |
| N1 | 0.98 (0.87–1.10) | 0.727 | – | – |
| N2 | 0.83 (0.70–0.98) | 0.026 | – | – |
| N3 | 0.92 (0.79–1.07) | 0.264 | – | – |
| Bone involvement | < 0.0001 | < 0.0001 | ||
| Yes | Reference | Reference | ||
| No | 0.84 (0.76–0.92) | < 0.0001 | 0.79 (0.71–0.88) | < 0.0001 |
| Liver involvement | < 0.0001 | < 0.0001 | ||
| Yes | Reference | Reference | ||
| No | 0.56 (0.51–0.62) | < 0.0001 | 0.62 (0.54–0.73) | < 0.0001 |
| Brain involvement | < 0.0001 | < 0.0001 | ||
| Yes | Reference | Reference | ||
| No | 0.58 (0.50–0.67) | < 0.0001 | 0.56 (0.51–0.63) | < 0.0001 |
| Surgery | < 0.0001 | < 0.0001 | ||
| No/unknown | Reference | Reference | ||
| Yes | 0.65 (0.59–0.73) | < 0.0001 | 0.67 (0.60–0.75) | < 0.0001 |
| Radiotherapy | 0.757 | – | ||
| No/unknown | Reference | – | – | |
| Yes | 0.98 (0.89–1.09) | 0.757 | – | – |
| Chemotherapy | < 0.0001 | < 0.0001 | ||
| No/unknown | Reference | Reference | ||
| Yes | 0.69 (0.63–0.76) | < 0.0001 | 0.56 (0.49–0.62) | < 0.0001 |