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. 2022 Mar 4;13:1185. doi: 10.1038/s41467-022-28587-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A–F Asymmetric FGF signaling and ligand-specific organization of DFM-specific (αCut, blue) and IFM-specific (αVg, blue) AMPs when dpp-Gal4 ectopically expressed either Pyr:GFP or Ths:GFP (dpp-Gal4>UAS-Pyr:GFP or Ths:GFP,>UAS-mCherryCAAX) in the wing disc pouch as illustrated in A; A Drawing depicting the experiments and results in B–F; dashed line, AMP-disc junctions; B’ XZ section from ROI in B; dashed and solid arrows, Cut and Vg expressing AMPs, respectively; double-sided arrow (D), proximal zone of Pyr:GFP expressing niche lacking Vg-positive AMPs. G, G”’ Wing disc pouch expressing Ths:GFP under dpp-Gal4 and showing mCherryCAAX-marked AMP and AMP cytonemes; *, proximal AMPs with orthogonal polarity and cytonemes; G”, G”’, single optical sections showing Ths:GFP on cytonemes (arrowheads); dashed lines, disc epithelium. H, H’ Wing disc pouch expressing Pyr:GFP under dpp-Gal4 and showing mCherryCAAX-marked AMP and AMP cytonemes; arrowhead, Pyr:GFP on cytonemes. I, J Models for the niche-specific asymmetric signaling and organization via cytonemes-mediated Pyr and Ths signaling (I) and signaling feedbacks reinforcing the cytoneme polarity and adhesion (J). Scale bars: 20 μm.