Table 2.
Baseline characteristics of patients with multi vessel coronary artery disease.
| Variables | 1 vessel | 2 vessels | ≥ 3 vessels | p value |
|---|---|---|---|---|
| N (%) | 287 (26.07%) | 310 (28.16%) | 504 (45.78%) | – |
| Age (years) | 54.52 ± 11.01 | 55.74 ± 11.32 | 54.41 ± 10.27 | 0.592 |
| Male (%) | 169 (58.89%) | 181 (58.39%) | 310 (61.51%) | 0.619 |
| BMI (kg/m2) | 25.92 ± 3.15 | 26.04 ± 3.38 | 26.28 ± 3.61 | 0.197 |
| Diabetes | 76 (26.48%) | 89 (28.71%) | 136 (26.98%) | 0.806 |
| Hypertension | 189 (65.85%) | 226 (72.90%) | 366 (72.62%) | 0.088 |
| Smoking | 88 (30.66%) | 84 (27.10%) | 117 (23.21%) | 0.067 |
| Consumers of alcohol | 81 (28.22%) | 96 (30.97%) | 168 (33.33%) | 0.325 |
| Laboratory variables | ||||
| FPG (mmol/L) | 6.52 ± 2.31 | 5.98 ± 2.06 | 5.91 ± 2.04 | 0.080 |
| HbA1c (%) | 6.14 ± 1.43 | 6.01 ± 1.35 | 5.97 ± 1.42 | 0.202 |
| ApoB (mg/dL) | 69.45 ± 27.23 | 85.53 ± 21.70 | 102.19 ± 28.79*# | < 0.001 |
| ApoA1 (mg/dL) | 135.42 ± 25.40 | 122.68 ± 29.34* | 119.14 ± 32.53* | < 0.001 |
| Total cholesterol (mmol/L) | 3.66 (1.31) | 4.24 (1.31)* | 5.21 (1.82)*# | < 0.001 |
| Triglycerides (mmol/L) | 1.31 (0.76) | 1.32 (0.58) | 1.41 (0.94) | 0.325 |
| HDL-C (mmol/L) | 0.88 (0.35) | 0.84 (0.30) | 0.86 (0.27) | 0.378 |
| LDL-C (mmol/L) | 2.26 (1.12) | 2.70 (0.99)* | 3.38 (1.41)*# | < 0.001 |
| sdLDL-C (mmol/L) | 0.59 (0.23) | 0.74 (0.26)* | 1.04 ( 0.51)*# | < 0.001 |
| hs-CRP (mg/L) | 4.59 (5.13) | 4.10 (6.33) | 3.10 (5.97)*# | 0.001 |
| HCY (μmol/L) | 11.85 (8.08) | 12.75 (12.74) | 12.17 (12.25) | 0.271 |
| Lp(a) (nmol/L) | 31.40 (41.32) | 40.09 (49.55)* | 45.23 (49.01)*# | < 0.001 |
| Minor allele frequency, N (%) | ||||
| SNP rs6415084 | 39 (13.59%) | 46 (18.84%) | 105 (20.83%)*# | 0.014 |
| SNP rs12194138 | 9 (3.14%) | 31 (10.00%)* | 35(6.94%)* | 0.004 |
Data are reported as means ± SD or n (%), median (interquartile ranges). SD: Standard deviation.
Statistical analysis was performed with the ANOVA or Kruskal–Wall test and and with Chi-square test for categorical variables.
BMI Body mass index, HbA1c Hemoglobin A1c, apoB Apolipoprotein B, apoA1 Apolipoprotein A1, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol, sdLDL-C Small dense low-density lipoprotein cholesterol, Hs-CRP Hypersensitive C-reactive protein, HCY Homocysteine, Lp(a) Lipoprotein(a).
*p < 0.05 compared with the 1 vessel group.
#p < 0.05 compared with the 2 vessels group.