Table 3.
Baseline characteristics of Gensini score in patients with coronary heart disease.
| Variables | Low GS | Intermediate GS | High GS | p value |
|---|---|---|---|---|
| N (%) | 378 (34.33%) | 354 (32.15%) | 369 (33.51%) | – |
| Age (years) | 54.84 ± 10.34 | 56.05 ± 10.14 | 54.71 ± 10.06 | 0.491 |
| Male (%) | 213 (56.35%) | 222(62.71%) | 225 (60.98%) | 0.189 |
| BMI (kg/m2) | 26.11 ± 3.25 | 25.98 ± 3.13 | 26.42 ± 3.33 | 0.452 |
| Diabetes | 117 (30.95%) | 87 (24.58%) | 97 (26.29%) | 0.132 |
| Hypertension | 257 (67.99%) | 262 (74.01%) | 262 (71.00%) | 0.200 |
| Smoking | 106 (28.04%) | 100 (28.25%) | 83 (22.49%) | 0.132 |
| Consumers of alcohol | 107 (28.31%) | 124 (35.03%) | 114 (30.89%) | 0.135 |
| Laboratory variables | ||||
| FPG (mmol/L) | 6.32 ± 2.51 | 6.06 ± 2.37 | 5.98 ± 1.91 | 0.486 |
| HbA1c (%) | 6.18 ± 1.43 | 5.95 ± 1.42 | 6.04 ± 1.35 | 0.174 |
| ApoB (mg/dL) | 73.66 ± 27.06 | 88.54 ± 22.02* | 105.31 ± 30.52*# | < 0.001 |
| ApoA1 (mg/dL) | 126.83 ± 29.37 | 123.47 ± 31.10 | 132.42 ± 27.07 | 0.057 |
| Total cholesterol (mmol/L) | 3.97 (1.19) | 4.45 (1.34)* | 5.22 (1.94)*# | < 0.001 |
| Triglycerides (mmol/L) | 1.15 (0.76) | 1.23 (0.57) | 1.59 (1.01)*# | < 0.001 |
| HDL-C (mmol/L) | 0.90 (0.33) | 0.87 (0.29) | 0.83 (0.25) | 0.332 |
| LDL-C (mmol/L) | 2.46 (1.29) | 2.77 (0.95)* | 3.54 (1.41)*# | < 0.001 |
| sdLDL-C (mmol/L) | 0.58 (0.62) | 0.80 (0.50)* | 1.09 (1.05)*# | < 0.001 |
| hs-CRP (mg/L) | 2.65 (6.01) | 4.06 (7.16) | 3.90 (7.12) | 0.643 |
| HCY (μmol/L) | 11.86 (11.14) | 12.61 (11.02) | 12.99 (12.78) | 0.138 |
| Lp(a) (nmol/L) | 32.72 (41.33) | 42.41 (56.80)* | 47.63 (58.48)* | < 0.001 |
| Minor allele frequency, N (%) | ||||
| SNP rs6415084 | 54 (14.29%) | 58 (16.38%) | 78 (21.14%)* | 0.040 |
| SNP rs12194138 | 17 (4.50%) | 23 (6.50%) | 35 (9.49%)* | 0.025 |
Data are reported as means ± SD or n(%), median (interquartile ranges). SD: Standard deviation.
Statistical analysis was performed with the ANOVA or Kruskal–Wall test and and with Chi-square test for categorical variables.
BMI Body mass index, HbA1c Hemoglobin A1c, apoB Apolipoprotein B, apoA1 Apolipoprotein A1, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol, sdLDL-C Small dense low-density lipoprotein cholesterol, Hs-CRP Hypersensitive C-reactive protein, HCY Homocysteine, Lp(a) Lipoprotein(a).
*p < 0.05 compared with the Low GS group.
#p < 0.05 compared with the Intermediate GS group.