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. 2022 Mar 4;8:95. doi: 10.1038/s41420-022-00901-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A LDH release assay was used to investigate the effect of edonerpic maleate on toxicity. B Calcein signal assay was used to investigate the effect of edonerpic maleate on cell viability. C, D LDH release assay (C) and calcein signal assay (D) were used to determine the therapeutic time window of edonerpic maleate. E, F Immunostaining (E) and quantification (F) showed that edonerpic maleate inhibited the expression of DMPO following TNI and glutamate treatment. G, H Edonerpic maleate reduced the levels of MDA (G) and 4-HNE (H) following TNI and glutamate treatment. Scale bar, 50 μm. Error bars indicate SEM. ^#p < 0.05 vs. Control. *p < 0.05 vs^. TNI + glutamate.