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. 2022 Mar 4;13:1237. doi: 10.1038/s41467-022-28936-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Ct regression coefficients, indicating an infection Ct relative to unvaccinated control group (dashed line), show an initial increase in Ct in the first month after the second vaccination dose, which then gradually diminishes. Increased Ct is restored after the booster, yet this regained effectiveness also gradually diminishes. Coefficients were obtained by multivariate linear regression analysis, adjusting for age, sex and calendric date (Methods; n = 22,657). Error bars represent one standard error of the mean. All P values are two sided: ‘ns’, not significant, *P < 0.05, **P < 0.01, ***P < 0.001. Data are shown for Ct of the RdRp gene; for genes N and E, see Supplementary Fig. 1a, b.